Genome-Centric Multimodal Data Integration in Personalised Cardiovascular Medicine.

University of Virginia

The University of Virginia (UVA) is a prestigious public research university located in Charlottesville, Virginia, USA. Founded in 1819 by Thomas Jefferson, UVA is renowned for its rigorous academics, innovative research, and commitment to public service. The Center for Public Health Genomics (CPHG) at UVA is a multidisciplinary research center dedicated to advancing our understanding of the genetic and genomic factors underlying human health and disease. Established in 2007, CPHG brings together experts from diverse fields such as genetics, epidemiology, bioinformatics, and public health to conduct cutting-edge research in genomics and its applications to public health. The center focuses on studying the genetic basis of complex diseases, developing novel genomic technologies, and translating research findings into public health interventions and policies. Through its collaborative and interdisciplinary approach, CPHG plays a critical role in addressing key public health challenges and improving health outcomes for populations worldwide.

Within he NextGen consortium UVA will provide expertise in integrating single-cell and spatial genomic and multiomic datasets from diverse populations to predict the early onset and progression of cardiovascular disease. The UVA team will serve as a use case to generalize federated artificial intelligence and bioinformatics algorithms for both atherosclerotic coronary artery disease and cardiomyopathies.